ICR 8000
Aurora Biomed’s ICR (Ion Channel Readers) combine the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) with our patented microsampling process and liquid handling technologies, creating a high-throughput screening solution for ion channel researchers that fills gaps which automated patch-clamp cannot. The ICR 8000 is a more affordable, mid-throughput ion channel screening system which is compact enough for the benchtop while retaining broad utility.
The ICR 8000 can be used to assess both voltage-gated (hERG, BK/SK, Kv1.1, 1.4, 1.5, KCNQ, 2P, etc.) and ligand-gated (KATP, nAChR, etc.) ion channels, as well as ion pumps and transporters (e.g., Na+/K+-ATPase), allowing researchers to accelerate drug development for the treatment and prevention of diseases associated with these key membrane transport proteins.
Current applications include the evaluation of the Cation-Chloride Cotransporter (CCC), a critical component of neuronal chloride homeostasis that is an essential regulator of cell volume and neuronal excitability. Because CCCs are electrically neutral, their activity cannot be measured using automated patch clamp techniques. The ICR 8000 is able to obtain high throughput activity measurements for these and other channels and transporters by measuring the absolute concentrations of cytosolic and extracellular ions, a technique that is independent of, and complimentary to, methods that rely on voltage manipulation.
Specifications
- Medium Throughput: Up to 5000 wells/day
- Single Channel: Measures 1 sample at a time
- Minimum sample volume: 50 µl
- Accommodation: 96/384-well microplates
- Footprint: H.67 cm X W.55 cm X D.37 cm
- Fuel Source: Acetylene / Compressed Air
- Options: Plate Stacker / Bar Code Reader
- Sensitivity: 0.05 ppm detection limit
- Precision: < 5% C
Features & Benefits
Programmable and automated solution for up to 5000 wells/day
Automatic dilution, calibration and cleaning
Adaptable to existing robotic automation
Sample dilution not required
High sensitivity
On-line dilution
Eliminates quenching effects associated with fluorescence
Removes need to work with hazardous radioisotopes
Avoids work restrictions posed by Rb’s short half-life
Ideal for hERG channel assays
Can assess both electrogenic and non-electrogenic transporters
For more information or to arrange a call from one of the Cea Analytical Team, please complete the contact form below. If your enquiry is urgent, please call us on 1300 552 725.
ICR 8000 Enquiry
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